TOP HAT study
A study looking at the effects of an anti-sickness treatment on Parkinson's disease or Lewy Body Dementia
What is the study about?
The study aims to determine if the drug Ondanstron (an anti-sickness treatment currently used in the NHS) will be an effective and well tolerated treatment for people with a diagnosis of Parkinson’s or Lewy Body Dementia who experience visual hallucinations.
What is involved?
Potential participants with receive a telephone call to discuss the research more fully and complete some questionnaires. This will be followed by a brief face-to-face visit to assess health, take a blood sample, and monitor heart rhythm. If eligible to take part, participants will either receive ondansetron or dummy medication tablets for 12 weeks, which will be shipped via a courier. The research team will maintain regular contact throughout to take assessments and let participants know how much medication to take. This contact will be by telephone, video call, and face-to-face. All face-to-face visits can take place either at participants’ homes or at a local study site. After taking the medication for 12 weeks, participants will be followed up for a further 12 weeks once treatment ends.
Who can take part?
People who:
- Have a diagnosis of Parkinson’s disease or Lewy Body Dementia
- Are experiencing visual hallucinations at least weekly
How can people get involved?
Please contact: Alice Locker (Clinical Studies Officer) alice.locker@nhs.net 07980 58455.